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101.
《Technovation》2017
Life science innovation has led to significant improvements in clinical outcomes and has been a source of financial growth for individuals and institutions capable of performing appropriate investments in this sector. Several groups have developed methodologies to assist medical technology innovators in the design and development activities. Unfortunately, these tools have not aided the general investment community to profit from these enterprises. This situation has contributed to a general reduction in risk capital directed towards life sciences compared to other industries. We review the current investment practices in the life science sector and present a comprehensive stage-gate model that aims to captures this investment process. An analysis of best practices and in-depth interviews with 68 life sciences investors and entrepreneurs worldwide are used to support such model. A single case-control study comparing life science investment execution within two similar investment firms was conducted to evaluate feasibility in the implementation of these practices. The stage-gate model includes (I) General vision and investment strategy definition; (II) Venture search, screening and rapid pre-evaluation; (III) Due diligence and negotiation of terms; (IV) Portfolio management, evaluation, and exit. The difference in execution of investment and results from a post-performance Root Cause Analysis were consistent with a reduction in perceived risk from the case company trained with the proposed model compared to the control. This suggests that our developed model and process may be useful in encouraging life sciences investment via evidence-based evaluations. 相似文献
102.
The last several decades have seen increases in patenting activity worldwide, as well as growing issues related to patent quality. In response to these quality issues a recent patent literature has emerged, that investigates the behavior and incentives of patent examiners, applicants, and third parties. In this paper, we provide an overview of patent procedures, patent systems and a survey of the new economic literature on patent systems. Both theoretical and empirical papers are considered. Policy implications coming from this literature are presented. 相似文献
103.
José Ángel Zúñiga‐Vicente César Alonso‐Borrego Francisco J. Forcadell José I. Galán 《Journal of economic surveys》2014,28(1):36-67
This survey examines the empirical literature on the relationship between public R&D subsidies and private R&D investment over the past five decades. The survey reveals a considerable heterogeneity of empirical results that cannot be explained fully by methodological issues. We aim to provide further explanations of the possible causes of that heterogeneity. In particular, we emphasise a set of issues that, in our view, are critical to understanding the potential effect of public R&D subsidies on private R&D spending. Special attention is paid to the dynamic aspects and composition of firm R&D, the constraints faced by the firm (such as financial constraints), and the amount and source of public subsidies. None of these issues have been investigated in depth. We formulate a set of research assumptions to guide future empirical research in this field. 相似文献
104.
客户协同创新是开放网络环境下企业创新能力提升的重要途径。基于协同理论、关系嵌入理论及客户参与创新等理论基础,对客户协同创新要素进行理论分析。采用探索性案例分析法,归纳客户协同创新要素特征,包括由互惠利益、关系质量和持续意愿构成的协同关系嵌入,由程序化协调、人际关系协调构成的协调协作机制,以及由信息资源分享、协同任务分担构成的协同资源投入。以案例研究结论为基础,进行量表开发,选择知识密集型服务业为实证对象,验证客户协同创新维度构成,可为客户协同创新机理研究与应用实践提供理论基础。 相似文献
105.
本文通过在一般均衡模型中引入银行部门,考察了金融发展对企业创新和经济增长的影响。基于模型的理论分析表明,在均衡状态下,金融发展可以提高经济中储蓄向投资转化的效率、缓解信息不对称,有效降低了研发部门的外部融资成本,从而促进企业增加研发投入,并推动经济实现更高速的增长。在此基础上,本文以中国31个省份2008—2016年的面板数据对上述结论进行了实证检验,相关结果表明:(1)金融发展对企业研发投入具有显著的促进效应;(2)在工业化程度、外商投资水平较高的地区以及政府支出水平较低、人才资源相对短缺的地区,金融发展的促进作用更加明显;(3)企业研发创新可以有效推动经济增长,且在金融支持实体经济中发挥了重要的中介作用。本文的理论和实证分析揭示了“金融发展—企业创新—经济增长”的内生性传导机理及其在中国的体现,从而为金融支持创新型经济增长的改革逻辑奠定了初步的理论和经验基础。 相似文献
106.
107.
《Futures》2016
The recent turn in research, technology and innovation (RTI) policy towards challenge-led strategies is posing new demands to Foresight methodology. RTI Foresight practitioners need to complement their well developed set of technology oriented methods with equally sophisticated approaches tackling societal aspects of innovation. In this paper we aim to make a contribution to this requirement. Building on user innovation theory we argue that demand oriented RTI Foresight needs to systematically integrate voices and hypotheses from the fringes of the innovation system. In order to develop a sound approach for this we set out from well established Foresight theory on “weak signals” and “cognitive biases”. Adopting a constructivist stance towards such signals leads us to the need to set up a socially robust, diverse discourse on “seeds of change hypotheses”. We then outline a practical implementation of such a discourse in the context of the recent Foresight process of the Federal Ministry of Education and Research (BMBF) in Germany. We describe and discuss the experience of this Foresight process and suggest avenues for further development of the approach. 相似文献
108.
109.
区域中心城市创新生态圈以生物学为隐喻,注重发挥创新主体的能动作用,能够放大区域中心城市发展优势。在回顾创新生态圈理论渊源的基础上,界定区域中心城市创新生态圈内涵,明确创新生态圈要素构成;以企业聚集发展为逻辑起点,探讨区域中心城市创新生态圈生态特征;基于生态学、创新理论等跨学科知识,构建区域中心城市创新生态圈演进模型,探究其运行机制。研究认为,区域中心城市创新生态圈具有开放式协同、动态自调节、多样性共生、自组织演化等生态特征,其运行机制由协同共生机制、风险识别与防控机制、利益分配机制和环境匹配机制共同组成。 相似文献
110.
创客组织是实现组织协同创新的重要载体。创客位于组织协同系统的核心层,创客入驻创客组织的创新状态决定了协同创新发展状态;创客组织位于组织协同系统的中间层,起组织协调作用,其发展稳定性影响着整个系统;协同组织位于外部层,其参与程度决定了整个系统的组织协同和协同创新吸引能力。基于波动系数计量模型,对240家创客组织的12项评价指标进行分析,结果显示,以高校主导的创客组织衡量指标波动系数为标准,创客组织在整体上处于发展不稳定状态;分类别分析结果表明,高校和科研院所主导的创客组织发展稳定性明显优于企业和个人主导的创客组织。研究结果可以为完善创新政策、促进创客组织稳健发展提供参考。 相似文献